![]() Based on satisfactory methodological homogeneity, data from 9 studies (468 participants) providing Quality of Life in Epilepsy-31 (QOLIE-31) outcomes were pooled for meta-analyses, showing significant mean changes for QOLIE-31 total score and 6 subscales. Twenty-four completed RCTs were included in this review (2439 participants). Standard methodological procedures required by the Cochrane Collaboration were used for data collection and analysis. A systematic literature search was conducted in line with Cochrane criteria for randomized controlled trials (RCTs) and quasi-RCTs investigating psychological treatments and using HRQoL outcome measures as primary or secondary outcome measures. The operational definition of psychological treatments included a broad range of interventions that use psychological or behavioral techniques designed to improve HRQoL, psychiatric comorbidities, and seizure frequency and severity for adults and children with epilepsy. An evaluation of the current evidence is needed to assess the effects of psychological treatments for PWE on HRQoL outcomes to inform future therapeutic recommendations and research designs. Given the significant impact epilepsy can have on health-related quality of life (HRQoL) of individuals with this condition and their families, there is great clinical interest in evidence-based psychological treatments aimed at enhancing well-being in people with epilepsy (PWE). 10 Academic Neurology Unit, Royal Hallamshire Hospital, University of Sheffield, Sheffield, UK.9 Department of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institute, Stockholm, Sweden.8 Department of Psychology, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.7 Departments of Psychiatry and Neurology, Rhode Island Hospital, Brown University, Providence, RI, USA.6 Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.5 College of Nursing and Department of Pediatrics, Medical University of South Carolina, Charleston, SC, USA.4 Division of Neurosurgery, Department of Surgery, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong.3 Department of Clinical Psychology, Prince of Wales Hospital, Hong Kong.1 Department of Neurology, Herdecke Community Hospital, University of Witten/Herdecke, Herdecke, Germany.
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